Menelik Watson left the field after suffering an injury during a 9-yard Trevor Siemian scramble with about 90 seconds left in the first half.
Watson, who appeared to be limping after the run, managed to play a couple more snaps before leaving the field and heading to the locker room.
Veteran offensive lineman Billy Turner replaced Watson at right tackle.
(Update by Ben Swanson)
7:46 p.m. MT: Quarterback Trevor Siemian exited Sunday’s game with 1:01 remaining in the second quarter after suffering an injury to his non-throwing shoulder.
The Broncos announced he is questionable to return.
Siemian suffered the injury while trying to tackle Janoris Jenkins as the New York Giants’ cornerback took a Siemian interception into the end zone for six points.
The Giants took a 17-3 lead on the play.
Brock Osweiler entered the game on the ensuing possession as the Broncos ran out the clock before halftime.
8:09 p.m. MT: Siemian was cleared to return. Watson was ruled out with a calf injury.
8:45 p.m. MT: Emmanuel Sanders suffered a right ankle injury when Giants safety Landon Collins took out Sanders at the legs while diving for a Siemian pass.
He has been ruled out for the remainder of Sunday’s game.
Collins, attempting to reel in an interception, hit Sanders from behind, and the Broncos’ wide receiver fell to the turf.
Trainers attended to Sanders on the field, and he was unable to put any weight on his right leg as he was helped off the field.
Sanders was then carted to the locker room.
8:57 p.m. MT: Isaiah McKenzie appeared to suffer a leg injury after getting tangled up with a Giants defender while diving for a deep Siemian pass.
Trainers evaluated McKenzie on the field for several minutes before a cart came out to take him to the locker room.
Injury update for the Broncos: WR Isaiah McKenzie (ankle) is out for the game.
— Patrick Smyth (@psmyth12) October 16, 2017